Metals in medicine: bioinorganic chemistry to fight infectious diseases and cancer.

Abstract

Metals have played a vital role in the field of medicine, underscoring the enduring connection between inorganic chemistry and healthcare. This thesis embarks on an exciting journey, harnessing the tools of bioinorganic chemistry, to address pressing biomedical healthcare challenges. With a primary aim to develop innovative metal-based compounds for diverse applications, the research explores antimicrobial resistance, antibacterial drug discovery, cancer therapeutics, and antiparasitic agents. Along this journey, novel bismuth(III), gallium(III), antimony(III), manganese(I), and gold(III) complexes have been synthesized and rigorously studied, providing valuable insights for future advancements. This thesis represents a significant stride towards simplifying the underlying chemistry, enhancing the assessment of biological activity, and fostering hope for pioneering therapeutic solutions in the ever-evolving healthcare landscape.