Please use this identifier to cite or link to this item:
https://hdl.handle.net/1889/3069
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Bacchi, Alessia | - |
dc.contributor.author | Capucci, Davide | - |
dc.date.accessioned | 2016-07-07T15:31:41Z | - |
dc.date.available | 2016-07-07T15:31:41Z | - |
dc.date.issued | 2016-03-04 | - |
dc.identifier.uri | http://hdl.handle.net/1889/3069 | - |
dc.description.abstract | Cocrystallization of the molecule of interest could be a smart and dainty way to tune solubility properties of solid phases leaving the molecule chemically unchanged, hence it is widely investigated by companies and by solid state scientists. Despite of this extremely high interest towards cocrystallization no particular emphasis has been paid to using it as a means to stabilize liquid molecules. In this work we define a benchmark of relevant molecules for human health that have been combined with suitable partners according to crystal engineering methods in order to obtain cocrystals. Solubility properties in different solvents of cocrystals new solid phases have been tested and compared to the properties of the drugs. A further approach to deal with volatile compounds is molecular confinement inside molecular scaffold. Nowadays metal organic frameworks (MOFs) are studied in many fields ranging from catalysis to trapping or storage of gases, such as hydrogen, methane, CO2 thanks to their extremely high porosity. Our goal is to confine liquid guests of biological relevance inside MOF pores, monitoring via X-ray diffraction, spectroscopy and thermal analysis the stabilization of the molecule of interest inside the cavities. | it |
dc.language.iso | Inglese | it |
dc.publisher | Università degli Studi di Parma. Dipartimento di Chimica | it |
dc.relation.ispartofseries | Dottorato di ricerca in Scienze Chimiche | it |
dc.rights | © Davide Capucci, 2016 | it |
dc.subject | Cocrystals | it |
dc.subject | X-ray | it |
dc.subject | MOF | it |
dc.subject | Crystallization | it |
dc.title | Stabilization of APIs and nutraceuticals through cocrystallization and molecular confinement | it |
dc.type | Doctoral thesis | it |
dc.subject.miur | Inorganic Chemistry, solid state chemistry | it |
Appears in Collections: | Scienze chimiche. Tesi di dottorato |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Tesi_Capucci.pdf | Tesi | 6.61 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.