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dc.contributor.advisorCorradini, Roberto-
dc.contributor.advisorDe Cola, Luisa-
dc.contributor.authorBertucci, Alessandro-
dc.description.abstractThe research work presented throughout this thesis focuses on the development of novel organic-inorganic hybrid materials for applications in nanotechnology, nanomedicine and diagnostics. In such a context, porous zeolite-L crystals have been used as nanocarriers to deliver either DNA or PNA in live cells, in combination with the release of guest molecules placed into the pores. Multifunctional mesoporous silica nanoparticles have been designed to treat glioblastoma, combining gene therapy with the sustained delivery of a chemotherapy agent. Biodegradable hybrid nano-shells have been furthermore created to encapsulate proteins and release them in living cells upon degradation of the outer structure in reductive environment. In the field of nucleic acid detection, photonic crystal fibers, functionalized with specific PNA probes, have been exploited as optical sensing devices to perform ultra-sensitive detection of DNA oligonucleotides or genomic DNA. Eventually, the PNA backbone has served as scaffold to synthesize fluorescent switching probes able to recognize and to detect the presence of specific target
dc.publisherUniversità di Parma. Dipartimento di Chimicait
dc.publisherUniversité de Strasbourg. Institut de science et d'ingénierie supramoléculairesit
dc.relation.ispartofseriesDottorato di ricerca in Scienze Chimicheit
dc.rights@ Alessandro Bertucci, 2015it
dc.subjectHybrid materialsit
dc.subjectPeptide nucleic acid (PNA)it
dc.subjectDNA detectionit
dc.titleHybrid organic-inorganic interfaces for biomedical applicationsit
dc.typeDoctoral thesisit
Appears in Collections:Scienze chimiche, Tesi di dottorato

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