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https://hdl.handle.net/1889/2841
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DC Field | Value | Language |
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dc.contributor.advisor | Corradini, Roberto | - |
dc.contributor.advisor | De Cola, Luisa | - |
dc.contributor.author | Bertucci, Alessandro | - |
dc.date.accessioned | 2015-08-04T06:17:48Z | - |
dc.date.available | 2015-08-04T06:17:48Z | - |
dc.date.issued | 2015-03-20 | - |
dc.identifier.uri | http://hdl.handle.net/1889/2841 | - |
dc.description.abstract | The research work presented throughout this thesis focuses on the development of novel organic-inorganic hybrid materials for applications in nanotechnology, nanomedicine and diagnostics. In such a context, porous zeolite-L crystals have been used as nanocarriers to deliver either DNA or PNA in live cells, in combination with the release of guest molecules placed into the pores. Multifunctional mesoporous silica nanoparticles have been designed to treat glioblastoma, combining gene therapy with the sustained delivery of a chemotherapy agent. Biodegradable hybrid nano-shells have been furthermore created to encapsulate proteins and release them in living cells upon degradation of the outer structure in reductive environment. In the field of nucleic acid detection, photonic crystal fibers, functionalized with specific PNA probes, have been exploited as optical sensing devices to perform ultra-sensitive detection of DNA oligonucleotides or genomic DNA. Eventually, the PNA backbone has served as scaffold to synthesize fluorescent switching probes able to recognize and to detect the presence of specific target sequences. | it |
dc.language.iso | Inglese | it |
dc.publisher | Università di Parma. Dipartimento di Chimica | it |
dc.publisher | Université de Strasbourg. Institut de science et d'ingénierie supramoléculaires | it |
dc.relation.ispartofseries | Dottorato di ricerca in Scienze Chimiche | it |
dc.rights | @ Alessandro Bertucci, 2015 | it |
dc.subject | Nanotechnology | it |
dc.subject | Hybrid materials | it |
dc.subject | Peptide nucleic acid (PNA) | it |
dc.subject | DNA detection | it |
dc.title | Hybrid organic-inorganic interfaces for biomedical applications | it |
dc.type | Doctoral thesis | it |
dc.subject.miur | CHIM/06 | it |
Appears in Collections: | Scienze chimiche. Tesi di dottorato |
Files in This Item:
File | Description | Size | Format | |
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THESIS_Bertucci.pdf | 136.44 MB | Adobe PDF | View/Open |
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