Please use this identifier to cite or link to this item: https://hdl.handle.net/1889/2494
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dc.contributor.advisorPalanza, Paola-
dc.contributor.advisorBartolomucci, Alessandro-
dc.contributor.authorCero, Cheryl-
dc.date.accessioned2014-07-18T08:01:03Z-
dc.date.available2014-07-18T08:01:03Z-
dc.date.issued2014-04-
dc.identifier.urihttp://hdl.handle.net/1889/2494-
dc.description.abstractVulnerability to stress is given by our genetic make-up and our experiences, therefore it differs between individuals since we are not genetically identical and do not experience the same life events. Moreover, even though stress has been associated obesity, some subjects lose weight instead under stressful conditions. The goal of this thesis is to undercover some of the molecular mechanisms underlying the individual susceptibility to stress which will allow us to better understand how individuals cope better than others. To answer our question we investigated key molecular player involved in adipogenesis, lipolysis, diabetogenesis, sympathetic and insulin signaling markers in metabolically active tissue coming from different strains of mice following exposure to chronic psychosocial stress. Our results showed that a stress induced a complex profile of pro-adipogenic and lipolytic-markers’ expression with a fat depot-specificity as well as strain specificity allowing the contemporary activation of catabolic and anabolic pathways to cope better with stress.it
dc.language.isoItalianoit
dc.publisherUniversità degli Studi di Parma. Dipartimento di Biologia evolutiva e funzionaleit
dc.relation.ispartofseriesDottorato di ricerca in Biologia del Comportamentoit
dc.rights©Cheryl Cero, 2014it
dc.subjectChronic Social Stressit
dc.subjectObesityit
dc.subjectMetabolic Syndromeit
dc.subjectAdipose Tissueit
dc.subjectNPYit
dc.subjectSympathetic Innernavaionit
dc.titleMolecular mechanisms and individual vulnerability in an animal model (Mus musculus) of obesity induced by chronic social stressit
dc.typeDoctoral thesisit
dc.subject.miurBIO/13it
Appears in Collections:Bioscienze. Tesi di dottorato

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